|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We thus demonstrated that overexpression of STK31 greatly inhibited tumorigenic growth and increased the chemosensitivity of HCT116 human colorectal carcinoma cells.
|
30144069 |
2019 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The STK31 gene was frequently expressed not only in colorectal cancer but also in gastric and esophageal cancer.
|
18281482 |
2008 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that STK31 is overexpressed in many human colorectal cancer cell lines and tissues.
|
24667656 |
2014 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The STK31 gene was frequently expressed not only in colorectal cancer but also in gastric and esophageal cancer.
|
18281482 |
2008 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that STK31 is overexpressed in many human colorectal cancer cell lines and tissues.
|
24667656 |
2014 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Reverse transcription-PCR analysis showed that STK31 gene expression levels in cancer samples were significantly higher (P < 0.0001) than those in normal samples.
|
18281482 |
2008 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
STK31 was confirmed as a CT gene in PC and its expression was significantly higher in patients with new neoplasm compared with patients without new neoplasm (P = 0.046) and in more advanced pathologic stages than in earlier stages (P = 0.002); methylation level correlated negatively with STK31 expression.
|
28422722 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Reverse transcription-PCR analysis showed that STK31 gene expression levels in cancer samples were significantly higher (P < 0.0001) than those in normal samples.
|
18281482 |
2008 |
|
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The STK31 gene was frequently expressed not only in colorectal cancer but also in gastric and esophageal cancer.
|
18281482 |
2008 |
|
Esophageal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The STK31 gene was frequently expressed not only in colorectal cancer but also in gastric and esophageal cancer.
|
18281482 |
2008 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
STK31 was confirmed as a CT gene in PC and its expression was significantly higher in patients with new neoplasm compared with patients without new neoplasm (P = 0.046) and in more advanced pathologic stages than in earlier stages (P = 0.002); methylation level correlated negatively with STK31 expression.
|
28422722 |
2017 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
STK31 was confirmed as a CT gene in PC and its expression was significantly higher in patients with new neoplasm compared with patients without new neoplasm (P = 0.046) and in more advanced pathologic stages than in earlier stages (P = 0.002); methylation level correlated negatively with STK31 expression.
|
28422722 |
2017 |
|
Malignant neoplasm of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The STK31 gene was frequently expressed not only in colorectal cancer but also in gastric and esophageal cancer.
|
18281482 |
2008 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Relative STK31 expression level was significantly higher in patients with lymph node metastasis.
|
28412729 |
2017 |
|
Polyp of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this case-control study, FBLN1 and STK31 serum levels were measured in 120 participants; 49 CRC patients (group I), 26 patients with benign colorectal polyps (group II) and 45 healthy controls (group III).
|
29715435 |
2018 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer.
|
28412729 |
2017 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
FBLN1 and STK31 can be possible screening and differentiating biomarkers of CRC.
|
29715435 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
Biomarker
|
disease |
BEFREE |
STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer.
|
28412729 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.040 |
Biomarker
|
disease |
BEFREE |
Serum FBLN1 and STK31 as biomarkers of colorectal cancer and their ability to noninvasively differentiate colorectal cancer from benign polyps.
|
29715435 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
We retrieve the majority of known cancer genes but also new candidates such as STK31 and MSRA with very high confidence.
|
27321817 |
2016 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The aim of this work is to evaluate Fibulin-1 (FBLN1) and serine threonine kinase-31 (STK31) as colorectal cancer (CRC) tumour markers and their ability to differentiate it from colorectal benign lesions.
|
29715435 |
2018 |
|
Malignant neoplasm of testis
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results showed that the new methodology in this study facilitated identification of CT antigens and that STK31 may be a candidate for cancer immunotherapy against gastrointestinal cancer.
|
18281482 |
2008 |
|
Malignant neoplasm of testis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The serine-threonine kinase 31 (STK31) gene is a novel cancer testis (CT) antigen.
|
28412729 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
We retrieve the majority of known cancer genes but also new candidates such as STK31 and MSRA with very high confidence.
|
27321817 |
2016 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these findings demonstrate that the STK31-PDCD5 complex network regulates apoptosis of cancer cells, and STK31 is a positive apoptosis regulator that inhibits tumorigenesis of colon cancer cells by inducing PDCD5-mediated apoptosis in response to genotoxic stress.
|
30144069 |
2019 |